The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.
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The human telomere sequence itself is a tandem repeat: Please help improve it or discuss these issues on the talk page. When shorter 10—bp tandem repeats were later identified, they came to be known as minisatellites.
You have entered an invalid code. Minisatellites have been implicated [ citation needed ] as regulators of gene expression e.
Add hypercariable Close comment form modal. While other genomes mouse, rat and pig contain minisatellite-like sequences, none was found to be hypermutable. I agree to the terms and conditions.
Dynamic evolution of megasatellites in yeasts. In alternative models, it is the presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations. Receive exclusive offers and updates from Oxford Academic.
Thank you for submitting a comment on this article. Additional analyses of DNA sequences flanking human minisatellites have also revealed an intense and highly localized meiotic crossover hotspot that is centered upstream of the unstable side of minisatellite arrays.
Hypervariable ‘minisatellite’ regions in human DNA
Such an event would ultimately lead to regons extinction of a hypermutable minisatellite by meiotic drive. Emery’s Elements of Medical Genetics, 12th. Please add a reason or a talk parameter to this template to explain the issue with the article.
The name “satellite” refers to the early observation that centrifugation of genomic DNA in a test tube separates a prominent layer of bulk DNA from accompanying “satellite” layers of repetitive DNA.
Close mobile search navigation Article navigation. H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing. Wikipedia articles i clarification from July All Wikipedia articles needing clarification Articles needing expert attention with no reason or talk parameter Articles needing expert attention from July All articles fegions expert attention Genetics articles needing expert attention Articles with multiple maintenance issues All articles with unsourced statements Articles with unsourced statements from May Studies have shown [ citation needed ] that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability.
Email alerts New issue alert. Oxford University Press is a department of the University of Oxford. Sign In or Create an Account. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements.
Hypervariable ‘minisatellite’ regions in human DNA – Semantic Scholar
Minisatellites were subsequently also used for genetic markers in linkage analysis and population studies, but were soon replaced by microsatellite profiling in the s. Sign in via your Institution Sign in. You regionw not currently have access to this article.
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Hypervariable ‘minisatellite’ regions in human DNA.
Sign In Forgot password? You could not be signed in. We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function. We present DNA sequences flanking cloned hypervariable human minisatellites. Studies have revealed distinct mutation processes operating in somatic and germline cells.